Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Elucidation of causal direction between asthma and obesity: a bi-directional Mendelian randomization study.

Authors: Xu, Shujing; Gilliland, Frank D; Conti, David V

Published In Int J Epidemiol, (2019 06 01)

Abstract: Observational associations between asthma and obesity are well established, but inferring causality is challenging. We leveraged publicly available summary statistics to ascertain the causal direction between asthma and obesity via Mendelian randomization in European-ancestry adults.We performed two-sample bi-directional Mendelian randomization analysis using publicly available genome-wide association studies summary statistics. Single nucleotide polymorphisms associated with asthma and body mass index at genome-wide significance were combined using a fixed effect meta-analysis in each direction. An extensive sensitivity analysis was considered.There was evidence in support of increasing causal effect of body mass index on risk of asthma (odds ratio 1.18 per unit increase, 95% confidence interval (CI) (1.11, 1.25), P = 2 × 10-8. No significant causal effect of asthma on adult body mass index was observed [estimate -0.004, 95% CI (-0.018, 0.009), P = 0.553].Our results confirmed that in European-ancestry populations, adult body mass index is likely to be causally linked to the risk of asthma; yet the effect of asthma on body mass index is small, if present at all.

PubMed ID: 31005996 Exiting the NIEHS site

MeSH Terms: Adult; Aged; Asthma/epidemiology*; Asthma/genetics; Body Mass Index; Causality; Female; Humans; Male; Mendelian Randomization Analysis; Middle Aged; Obesity/epidemiology*; Obesity/genetics; Odds Ratio; Polymorphism, Single Nucleotide; United Kingdom/epidemiology

Back
to Top