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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Cardiac Autonomic Effects of Secondhand Exposure to Nicotine from Electronic Cigarettes: An Exploratory Study.

Authors: Lee, Mi-Sun; Rees, Vaughan W; Koutrakis, Petros; Wolfson, Jack M; Son, Youn-Suk; Lawrence, Joy; Christiani, David C

Published In Environ Epidemiol, (2019 Feb)

Abstract: BACKGROUND: The rapid increase in prevalence of e-cigarette (EC) use may lead to widespread exposure to secondhand emissions among nonsmokers, but evidence on the potential cardiovascular health risks is limited. We aimed to investigate effect of short-term secondhand exposure to nicotine from e-cigarette (EC) emissions on cardiac autonomic function using heart rate variability (HRV). METHODS: A randomized, repeated measures crossover study of healthy nonsmoking volunteers was conducted. Standard deviation of NN intervals (SDNN), average of the standard deviation of NN intervals (ASDNN), root mean square of successive differences (rMSSD), and heart rate-corrected QT interval (QTc) were calculated during one hour of EC exposure session. RESULTS: Nicotine from EC emissions was associated with a 7.8% decrease in SDNN (95% CI, -11.2% to -4.3%), 7.7% decrease in ASDNN (95% CI, -11.0% to -4.2%) and 3.8 msec decrease in QTc (95% CI, -5.8 to -1.9). Compared with a short exposure time period (<15min), greater nicotine associated with reductions in ASDNN (P for interaction = 0.076) with longer exposure time periods. For QTc, greater nicotine associated with reductions were found during 15-30 min exposure time period (P for interaction = 0.04). CONCLUSION: We present the first evidence of cardiac autonomic effects of short-term secondhand exposure to nicotine from EC emissions among healthy nonsmokers. Further comprehensive research on EC exposure extending to more subjects and flavor compounds is warranted.

PubMed ID: 31656942 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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