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Publication Detail

Title: Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification.

Authors: La Merrill, Michele A; Vandenberg, Laura N; Smith, Martyn T; Goodson, William; Browne, Patience; Patisaul, Heather B; Guyton, Kathryn Z; Kortenkamp, Andreas; Cogliano, Vincent J; Woodruff, Tracey J; Rieswijk, Linda; Sone, Hideko; Korach, Kenneth S; Gore, Andrea C; Zeise, Lauren; Zoeller, R Thomas

Published In Nat Rev Endocrinol, (2020 01)

Abstract: Endocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with hormone action, thereby increasing the risk of adverse health outcomes, including cancer, reproductive impairment, cognitive deficits and obesity. A complex literature of mechanistic studies provides evidence on the hazards of EDC exposure, yet there is no widely accepted systematic method to integrate these data to help identify EDC hazards. Inspired by work to improve hazard identification of carcinogens using key characteristics (KCs), we have developed ten KCs of EDCs based on our knowledge of hormone actions and EDC effects. In this Expert Consensus Statement, we describe the logic by which these KCs are identified and the assays that could be used to assess several of these KCs. We reflect on how these ten KCs can be used to identify, organize and utilize mechanistic data when evaluating chemicals as EDCs, and we use diethylstilbestrol, bisphenol A and perchlorate as examples to illustrate this approach.

PubMed ID: 31719706 Exiting the NIEHS site

MeSH Terms: Animals; Consensus*; Endocrine Disruptors/adverse effects*; Environmental Exposure/adverse effects*; Environmental Exposure/prevention & control; Environmental Pollutants/adverse effects*; Environmental Pollutants/metabolism; Humans; Receptors, Corticotropin/metabolism

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