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Publication Detail

Title: Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking.

Authors: Sikdar, Sinjini; Joehanes, Roby; Joubert, Bonnie R; Xu, Cheng-Jian; Vives-Usano, Marta; Rezwan, Faisal I; Felix, Janine F; Ward, James M; Guan, Weihua; Richmond, Rebecca C; Brody, Jennifer A; Küpers, Leanne K; Baïz, Nour; Håberg, Siri E; Smith, Jennifer A; Reese, Sarah E; Aslibekyan, Stella; Hoyo, Cathrine; Dhingra, Radhika; Markunas, Christina A; Xu, Tao; Reynolds, Lindsay M; Just, Allan C; Mandaviya, Pooja R; Ghantous, Akram; Bennett, Brian D; Wang, Tianyuan; Consortium, The Bios; Bakulski, Kelly M; Melen, Erik; Zhao, Shanshan; Jin, Jianping; Herceg, Zdenko; Meurs, Joyce van; Taylor, Jack A; Baccarelli, Andrea A; Murphy, Susan K; Liu, Yongmei; Munthe-Kaas, Monica Cheng; Deary, Ian J; Nystad, Wenche; Waldenberger, Melanie; Annesi-Maesano, Isabella; Conneely, Karen; Jaddoe, Vincent Wv; Arnett, Donna; Snieder, Harold; Kardia, Sharon Lr; Relton, Caroline L; Ong, Ken K; Ewart, Susan; Moreno-Macias, Hortensia; Romieu, Isabelle; Sotoodehnia, Nona; Fornage, Myriam; Motsinger-Reif, Alison; Koppelman, Gerard H; Bustamante, Mariona; Levy, Daniel; London, Stephanie J

Published In Epigenomics, (2019 10)

Abstract: Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.

PubMed ID: 31536415 Exiting the NIEHS site

MeSH Terms: Adult; Cohort Studies; CpG Islands; DNA Methylation*; Epigenesis, Genetic; Epigenomics/methods*; Female; Humans; Infant, Newborn; Maternal Exposure/adverse effects; Pregnancy; Prenatal Exposure Delayed Effects/epidemiology; Prenatal Exposure Delayed Effects/genetics*; Tobacco Smoking/epidemiology; Tobacco Smoking/genetics*

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