Title: Effects of Preconception and in Utero Inorganic Arsenic Exposure on the Metabolic Phenotype of Genetically Diverse Collaborative Cross Mice.
Authors: Fry, Rebecca C; Addo, Kezia A; Bell, Timothy A; Douillet, Christelle; Martin, Elizabeth; Stýblo, Miroslav; Pardo-Manuel de Villena, Fernando
Published In Chem Res Toxicol, (2019 08 19)
Abstract: In humans and mice, in utero exposure to inorganic arsenic (iAs) is associated with adverse health outcomes later in life. The contribution of preconception exposure to the adverse outcomes in offspring has never been studied. Here combined in utero and postnatal exposures produce insulin resistance in two collaborative cross strains. Furthermore, combined preconception and in utero exposure resulted in increased birth weight and developed insulin resistance in one strain. Thus, preconception exposure to arsenic may contribute to the metabolic disorders later in life, but the susceptibility to the effects of this exposure is determined, at least in part, by genetics.
PubMed ID: 31251040
MeSH Terms: Animals; Arsenic/administration & dosage; Arsenic/metabolism*; Arsenic/toxicity*; Collaborative Cross Mice; Female; Fetal Development/drug effects*; Fetal Development/genetics; Male; Mice; Phenotype; Pregnancy; Uterus/drug effects*; Uterus/metabolism