Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: Metabolomics of childhood exposure to perfluoroalkyl substances: a cross-sectional study.

Authors: Kingsley, Samantha L; Walker, Douglas I; Calafat, Antonia M; Chen, Aimin; Papandonatos, George D; Xu, Yingying; Jones, Dean P; Lanphear, Bruce P; Pennell, Kurt D; Braun, Joseph M

Published In Metabolomics, (2019 06 21)

Abstract: Exposure to perfluoroalkyl substances (PFAS), synthetic and persistent chemicals used in commercial and industrial processes, are associated with cardiometabolic dysfunction and related risk factors including reduced birth weight, excess adiposity, and dyslipidemia. Identifying the metabolic changes induced by PFAS exposure could enhance our understanding of biological pathways underlying PFAS toxicity.To identify metabolic alterations associated with serum concentrations of four PFAS in children using a metabolome-wide association study.We performed untargeted metabolomic profiling by liquid chromatography with ultra-high-resolution mass spectrometry, and separately quantified serum concentrations of perfluorooctanoic acid, perfluorooctanesulfonic acid, perfluorononanoic acid, and perfluorohexanesulfonic acid (PFHxS) for 114 8-year old children from Cincinnati, OH. We evaluated associations between each serum PFAS concentration and 16,097 metabolic features using linear regression adjusted for child age, sex, and race with a false discovery rate < 20%. We annotated PFAS-associated metabolites and conducted pathway enrichment analyses.Serum PFAS concentrations were associated with metabolic features annotated primarily as lipids and dietary factors. Biological pathways associated with all four PFAS included arginine, proline, aspartate, asparagine, and butanoate metabolism.In this cross-sectional study, childhood serum PFAS concentrations were correlated with metabolic pathways related to energy production and catabolism. Future studies should determine whether these pathways mediate associations between PFAS exposure and childhood cardiometabolic health.

PubMed ID: 31227916 Exiting the NIEHS site

MeSH Terms: Alkanesulfonic Acids/blood; Caprylates/blood; Child; Cross-Sectional Studies; Energy Metabolism; Environmental Exposure*; Female; Fluorocarbons/blood*; Fluorocarbons/metabolism; Humans; Linear Models; Lipids/blood; Male; Metabolic Networks and Pathways; Metabolomics*; Sulfonic Acids/blood

Back
to Top