Title: Prenatal and Childhood Traffic-Related Air Pollution Exposure and Telomere Length in European Children: The HELIX Project.
Authors: Clemente, Diana B P; Vrijheid, Martine; Martens, Dries S; Bustamante, Mariona; Chatzi, Leda; Danileviciute, Asta; de Castro, Montserrat; Grazuleviciene, Regina; Gutzkow, Kristine B; Lepeule, Johanna; Maitre, Lea; McEachan, Rosie R C; Robinson, Oliver; Schwarze, Per E; Tamayo, Ibon; Vafeiadi, Marina; Wright, John; Slama, Rémy; Nieuwenhuijsen, Mark; Nawrot, Tim S
Published In Environ Health Perspect, (2019 08)
Abstract: Telomere length is a molecular marker of biological aging.Here we investigated whether early-life exposure to residential air pollution was associated with leukocyte telomere length (LTL) at 8 y of age.In a multicenter European birth cohort study, HELIX (Human Early Life Exposome) ([Formula: see text]), we estimated prenatal and 1-y childhood exposure to nitrogen dioxide ([Formula: see text]), particulate matter with aerodynamic diameter [Formula: see text] ([Formula: see text]), and proximity to major roads. Average relative LTL was measured using quantitative real-time polymerase chain reaction (qPCR). Effect estimates of the association between LTL and prenatal, 1-y childhood air pollution, and proximity to major roads were calculated using multiple linear mixed models with a random cohort effect and adjusted for relevant covariates.LTL was inversely associated with prenatal and 1-y childhood [Formula: see text] and [Formula: see text] exposures levels. Each standard deviation (SD) increase in prenatal [Formula: see text] was associated with a [Formula: see text] (95% CI: [Formula: see text], [Formula: see text]) change in LTL. Prenatal [Formula: see text] was nonsignificantly associated with LTL ([Formula: see text] per SD increase; 95% CI: [Formula: see text], 0.6). For each SD increment in 1-y childhood [Formula: see text] and [Formula: see text] exposure, LTL shortened by [Formula: see text] (95% CI: [Formula: see text], [Formula: see text]) and [Formula: see text] (95% CI: [Formula: see text], 0.1), respectively. Each doubling in residential distance to nearest major road during childhood was associated with a 1.6% (95% CI: 0.02, 3.1) lengthening in LTL.Lower exposures to air pollution during pregnancy and childhood were associated with longer telomeres in European children at 8 y of age. These results suggest that reductions in traffic-related air pollution may promote molecular longevity, as exemplified by telomere length, from early life onward. https://doi.org/10.1289/EHP4148.
PubMed ID: 31393792
MeSH Terms: Air Pollutants/analysis*; Air Pollution/analysis*; Child, Preschool; Cohort Studies; Environmental Exposure*; Europe; Female; Humans; Infant; Leukocytes/cytology; Male; Maternal Exposure; Nitrogen Dioxide/analysis; Particulate Matter/analysis; Pregnancy; Telomere Shortening/drug effects*; Traffic-Related Pollution/analysis*