Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Dietary Fiber-Induced Microbial Short Chain Fatty Acids Suppress ILC2-Dependent Airway Inflammation.

Authors: Lewis, Gavin; Wang, Bowen; Shafiei Jahani, Pedram; Hurrell, Benjamin P; Banie, Homayon; Aleman Muench, German R; Maazi, Hadi; Helou, Doumet Georges; Howard, Emily; Galle-Treger, Lauriane; Lo, Richard; Santosh, Swetha; Baltus, Andrew; Bongers, Gerrold; San-Mateo, Lani; Gilliland, Frank D; Rehan, Virender K; Soroosh, Pejman; Akbari, Omid

Published In Front Immunol, (2019)

Abstract: Group 2 Innate lymphoid cells (ILC2) contribute significantly to allergic inflammation. However, the role of microbiota on ILC2s remains to be unraveled. Here we show that short chain fatty acids (SCFAs), such as butyrate, derived from fermentation of dietary fibers by the gut microbiota inhibit pulmonary ILC2 functions and subsequent development of airway hyperreactivity (AHR). We further show that SCFAs modulate GATA3, oxidative phosphorylation, and glycolytic metabolic pathways in pulmonary ILC2s. The observed phenotype is associated with increased IL-17a secretion by lung ILC2s and linked to enhanced neutrophil recruitment to the airways. Finally, we show that butyrate-producing gut bacteria in germ-free mice effectively suppress ILC2-driven AHR. Collectively, our results demonstrate a previously unrecognized role for microbial-derived SCFAs on pulmonary ILC2s in the context of AHR. The data suggest strategies aimed at modulating metabolomics and microbiota in the gut, not only to treat, but to prevent lung inflammation and asthma.

PubMed ID: 31620118 Exiting the NIEHS site

MeSH Terms: Animals; Asthma*/immunology; Asthma*/microbiology; Asthma*/pathology; Butyric Acid/immunology*; Dietary Fiber/administration & dosage*; Gastrointestinal Microbiome*/drug effects; Gastrointestinal Microbiome*/immunology; Immunity, Innate/drug effects; Inflammation/immunology; Inflammation/pathology; Lymphocytes/immunology*; Lymphocytes/pathology; Mice; Mice, Inbred BALB C; Mice, Knockout; Neutrophils/immunology*; Neutrophils/pathology

to Top