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Title: Role of extracellular vesicles in cell-cell communication and inflammation following exposure to pulmonary toxicants.

Authors: Andres, Jaclynn; Smith, Ley Cody; Murray, Alexa; Jin, Yang; Businaro, Rita; Laskin, Jeffrey D; Laskin, Debra L

Published In Cytokine Growth Factor Rev, (2020 Feb)

Abstract: Extracellular vesicles (EVs) have emerged as key regulators of cell-cell communication during inflammatory responses to lung injury induced by diverse pulmonary toxicants including cigarette smoke, air pollutants, hyperoxia, acids, and endotoxin. Many lung cell types, including epithelial cells and endothelial cells, as well as infiltrating macrophages generate EVs. EVs appear to function by transporting cargo to recipient cells that, in most instances, promote their inflammatory activity. Biologically active cargo transported by EVs include miRNAs, cytokines/chemokines, damage-associated molecular patterns (DAMPs), tissue factor (TF)s, and caspases. Findings that EVs are taken up by target cells such as macrophages, and that this leads to increased proinflammatory functioning provide support for their role in the development of pathologies associated with toxicant exposure. Understanding the nature of EVs responding to toxic exposures and their cargo may lead to the development of novel therapeutic approaches to mitigating lung injury.

PubMed ID: 31901309 Exiting the NIEHS site

MeSH Terms: Animals; Cell Communication/drug effects*; Chemokines/metabolism; Cytokines/metabolism; Endothelial Cells/drug effects; Epithelial Cells/drug effects*; Extracellular Vesicles/physiology*; Hazardous Substances/pharmacology*; Hazardous Substances/toxicity; Humans; Inflammation/etiology*; Lung/drug effects*; Lung/immunology; Lung/pathology; Mice

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