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National Institute of Environmental Health Sciences

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Publication Detail

Title: Leukocyte Traits and Exposure to Ambient Particulate Matter Air Pollution in the Women's Health Initiative and Atherosclerosis Risk in Communities Study.

Authors: Gondalia, Rahul; Holliday, Katelyn M; Baldassari, Antoine; Justice, Anne E; Stewart, James D; Liao, Duanping; Yanosky, Jeff D; Engel, Stephanie M; Jordahl, Kristina M; Bhatti, Parveen; Horvath, Steve; Assimes, Themistocles L; Pankow, James S; Demerath, Ellen W; Guan, Weihua; Fornage, Myriam; Bressler, Jan; North, Kari E; Conneely, Karen N; Li, Yun; Hou, Lifang; Baccarelli, Andrea A; Whitsel, Eric A

Published In Environ Health Perspect, (2020 Jan)

Abstract: BACKGROUND: Inflammatory effects of ambient particulate matter (PM) air pollution exposures may underlie PM-related increases in cardiovascular disease risk and mortality, although evidence of PM-associated leukocytosis is inconsistent and largely based on small, cross-sectional, and/or unrepresentative study populations. OBJECTIVES: Our objective was to estimate PM-leukocyte associations among U.S. women and men in the Women's Health Initiative and Atherosclerosis Risk in Communities study (). METHODS: We based the PM-leukocyte estimations on up to four study visits per participant, at which peripheral blood leukocytes and geocoded address-specific concentrations of , , and in diameter (, , and , respectively) were available. We multiply imputed missing data using chained equations and estimated PM-leukocyte count associations over daily to yearly PM exposure averaging periods using center-specific, linear, mixed, longitudinal models weighted for attrition and adjusted for sociodemographic, behavioral, meteorological, and geographic covariates. In a subset of participants with available data (), we also estimated PM-leukocyte proportion associations in compositional data analyses. RESULTS: We found a (95% confidence interval: , 33) higher leukocyte count, a 1.2% (0.6%, 1.8%) higher granulocyte proportion, and a (, ) lower T-cell proportion per increase in 1-month mean . However, shorter-duration exposures were inversely and only modestly associated with leukocyte count. DISCUSSION: The -leukocyte estimates, albeit imprecise, suggest that among racially, ethnically, and environmentally diverse U.S. populations, sustained, ambient exposure to fine PM may induce subclinical, but epidemiologically important, inflammatory effects. https://doi.org/10.1289/EHP5360.

PubMed ID: 31903802 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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