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Title: Liver Stiffness Severity is Associated With Increased Cardiovascular Risk in Patients With Type 2 Diabetes.

Authors: Mangla, Neeraj; Ajmera, Veeral H; Caussy, Cyrielle; Sirlin, Claude; Brouha, Sharon; Bajwa-Dulai, Sonia; Madamba, Egburt; Bettencourt, Ricki; Richards, Lisa; Loomba, Rohit

Published In Clin Gastroenterol Hepatol, (2020 03)

Abstract: Cardiovascular disease (CVD) is the leading cause of death among patients with nonalcoholic fatty liver disease (NAFLD) and is strongly associated with type 2 diabetes mellitus (DM2).1 Accurately assessing CVD risk in NAFLD patients is critical to improving clinical outcomes.1 Use of liver stiffness measurements to noninvasively assess for liver fibrosis is broadening, and magnetic resonance elastography (MRE) is the most accurate modality in NAFLD.2 However, the association between fibrosis severity on MRE and the degree of CVD risk is unknown. The aim of this study was to determine whether MRE-assessed liver fibrosis stage is associated with CVD risk determined by Framingham risk score (FRS) and coronary artery calcium (CAC).

PubMed ID: 31100460 Exiting the NIEHS site

MeSH Terms: Cardiovascular Diseases*/epidemiology; Cross-Sectional Studies; Diabetes Mellitus, Type 2*/complications; Elasticity Imaging Techniques*; Heart Disease Risk Factors; Humans; Liver Cirrhosis/complications; Liver Cirrhosis/epidemiology; Liver Cirrhosis/pathology; Liver/diagnostic imaging; Liver/pathology; Non-alcoholic Fatty Liver Disease*/complications; Non-alcoholic Fatty Liver Disease*/pathology; Risk Factors

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