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Title: Sleep and neurocognitive decline in the Hispanic Community Health Study/Study of Latinos.

Authors: Ramos, Alberto R; Tarraf, Wassim; Wu, Benson; Redline, Susan; Cai, Jianwen; Daviglus, Martha L; Gallo, Linda; Mossavar-Rahmani, Yasmin; Perreira, Krista M; Zee, Phyllis; Zeng, Donglin; Gonzalez, Hector M

Published In Alzheimers Dement, (2020 02)

Abstract: INTRODUCTION: To determine if sleep-disordered breathing (SDB), daytime sleepiness, insomnia, and sleep duration predict seven-year neurocognitive decline in US Hispanics/Latinos (N = 5247). METHODS: The exposures were baseline SDB, daytime sleepiness, insomnia, and sleep duration. The outcomes were change in episodic learning and memory (B-SEVLT-Sum and SEVLT-Recall), language (word fluency [WF]), processing speed (Digit Symbol Substitution), and a cognitive impairment screener (Six-item Screener [SIS]). RESULTS: Mean age was 63 ± 8 years, with 55% of the population being female with 7.0% Central American, 24.5% Cuban, 9.3% Dominican, 35.9% Mexican, 14.4% Puerto Rican, and 5.1% South American background. Long sleep (>9 hours), but not short sleep (<6 hours), was associated with decline (standard deviation units) in episodic learning and memory (βSEVLT-Sum = -0.22 [se = 0.06]; P < .001; βSEVLT-Recall = -0.13 [se = 0.06]; P < .05), WF (Pwf = -0.20 [se 5 0.06]; P < .01), and SIS (βSIS = -0.16 [se = 0.06]; P < .01), but not processing speed, after adjusting for covariates. SDB, sleepiness, and insomnia were not associated with neurocognitive decline. CONCLUSION: Long sleep duration predicted seven-year cognitive decline.

PubMed ID: 31606367 Exiting the NIEHS site

MeSH Terms: Aged; Central America; Cognitive Dysfunction/ethnology*; Female; Hispanic Americans/statistics & numerical data*; Humans; Male; Middle Aged; Neuropsychological Tests/statistics & numerical data; Public Health*; Puerto Rico; Sleep Apnea Syndromes; Sleep Initiation and Maintenance Disorders; Sleep Wake Disorders*; South America; Surveys and Questionnaires; Time Factors

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