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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Tissue Papers: Leveraging Paper-Based Microfluidics for the Next Generation of 3D Tissue Models.

Authors: Cramer, Sabrina M; Larson, Tyler S; Lockett, Matthew R

Published In Anal Chem, (2019 Sep 03)

Abstract: Paper-based scaffolds support the three-dimensional culture of mammalian cells in tissue-like environments. These Tissue Papers, a name that highlights the use of materials obtained from (plant) tissue to generate newly functioning (human) tissue structures, are a promising analytical tool to quantify cellular responses in physiologically relevant extracellular gradients and coculture architectures. Here, we highlight current examples of Tissue Papers, commonly used methods of analysis, and current measurement challenges.

PubMed ID: 31356054 Exiting the NIEHS site

MeSH Terms: Animals; Cell Culture Techniques/instrumentation*; Cell Movement; Cellulose/chemistry*; Extracellular Matrix/chemistry; Fibroblasts/cytology; Fibroblasts/physiology; Hepatocytes/cytology; Hepatocytes/physiology; Human Umbilical Vein Endothelial Cells/cytology; Human Umbilical Vein Endothelial Cells/physiology; Humans; Hydrogels/chemistry; Lab-On-A-Chip Devices*; Models, Biological; Myocytes, Cardiac/cytology; Myocytes, Cardiac/physiology; Paper; Tissue Engineering/instrumentation; Tissue Engineering/methods*; Tissue Scaffolds

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