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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Viruses and non-allergen environmental triggers in asthma.

Authors: Chau-Etchepare, Florence; Hoerger, Joshua L; Kuhn, Brooks T; Zeki, Amir A; Haczku, Angela; Louie, Samuel; Kenyon, Nicholas J; Davis, Cristina E; Schivo, Michael

Published In J Investig Med, (2019 10)

Abstract: Asthma is a complex inflammatory disease with many triggers. The best understood asthma inflammatory pathways involve signals characterized by peripheral eosinophilia and elevated immunoglobulin E levels (called T2-high or allergic asthma), though other asthma phenotypes exist (eg, T2-low or non-allergic asthma, eosinophilic or neutrophilic-predominant). Common triggers that lead to poor asthma control and exacerbations include respiratory viruses, aeroallergens, house dust, molds, and other organic and inorganic substances. Increasingly recognized non-allergen triggers include tobacco smoke, small particulate matter (eg, PM2.5), and volatile organic compounds. The interaction between respiratory viruses and non-allergen asthma triggers is not well understood, though it is likely a connection exists which may lead to asthma development and/or exacerbations. In this paper we describe common respiratory viruses and non-allergen triggers associated with asthma. In addition, we aim to show the possible interactions, and potential synergy, between viruses and non-allergen triggers. Finally, we introduce a new clinical approach that collects exhaled breath condensates to identify metabolomics associated with viruses and non-allergen triggers that may promote the early management of asthma symptoms.

PubMed ID: 31352362 Exiting the NIEHS site

MeSH Terms: Air Pollution/adverse effects; Allergens/immunology*; Animals; Asthma/immunology*; Asthma/virology*; Environment*; Humans; Smoking/adverse effects; Viruses/immunology*

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