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Title: Residential proximity to roadways and placental-associated stillbirth: a case-control study.

Authors: Butler, Lindsey; Gallagher, Lisa; Winter, Michael; Fabian, M Patricia; Wesselink, Amelia; Aschengrau, Ann

Published In Int J Environ Health Res, (2021 Jun)

Abstract: We conducted a retrospective case-control study of 1,097 women in Massachusetts and Rhode Island, USA, to examine the association between stillbirth related to placental abruption or placental insufficiency and maternal exposure to traffic-related air pollution. We utilized distance to nearest roadway proximity metrics as a proxy for traffic-related air pollution exposure. No meaningful increase in the overall odds of placental-associated stillbirths was observed (adjusted OR: 1.1, 95% CI: 0.5-2.8). However, mothers living within 50 m of a roadway had a 60% increased odds of experiencing a stillbirth related to placental abruption compared to mothers living greater than 200 m away. This suggestive finding was imprecise due to the small case number in the highest exposure category (95% CI: 0.6-4.0). Future studies of placental abruption with more precise exposure assessments are warranted.

PubMed ID: 31587563 Exiting the NIEHS site

MeSH Terms: Abruptio Placentae/epidemiology*; Abruptio Placentae/etiology; Adult; Air Pollution/adverse effects*; Case-Control Studies; Female; Humans; Massachusetts/epidemiology; Maternal Exposure/adverse effects*; Placental Insufficiency/epidemiology*; Placental Insufficiency/etiology; Pregnancy; Retrospective Studies; Rhode Island/epidemiology; Stillbirth/epidemiology*; Traffic-Related Pollution/adverse effects*; Young Adult

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