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Publication Detail

Title: The impact of manganese on neurotransmitter systems.

Authors: Soares, Ana Thalita Gonçalves; Silva, Aline de Castro; Tinkov, Alexey A; Khan, Haroon; Santamaría, Abel; Skalnaya, Margarita G; Skalny, Anatoly V; Tsatsakis, Aristidis; Bowman, Aaron B; Aschner, Michael; Ávila, Daiana Silva

Published In J Trace Elem Med Biol, (2020 May 20)

Abstract: BACKGROUND: Manganese (Mn) is a metal ubiquitously present in nature and essential for many living organisms. As a trace element, it is required in small amounts for the proper functioning of several important enzymes, and reports of Mn deficiency are indeed rare. METHODS: This mini-review will cover aspects of Mn toxicokinetics and its impact on brain neurotransmission, as well as its Janus-faced effects on humans and other animal's health. RESULTS: The estimated safe upper limit of intracellular Mn for physiological function is in anarrow range of 20-53 μM.Therefore, intake of higher levels of Mn and the outcomes, especially to the nervous system, have been well documented. CONCLUSION: The metal affects mostly the brain by accumulating in specific areas, altering cognitive functions and locomotion, thus severely impacting the health of the exposed organisms.

PubMed ID: 32480053 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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