Title: Serum amyloid A is a soluble pattern recognition receptor that drives type 2 immunity.

Authors: Smole, Ursula; Gour, Naina; Phelan, Jordan; Hofer, Gerhard; Köhler, Cordula; Kratzer, Bernhard; Tauber, Peter A; Xiao, Xiao; Yao, Nu; Dvorak, Jan; Caraballo, Luis; Puerta, Leonardo; Rosskopf, Sandra; Chakir, Jamila; Malle, Ernst; Lane, Andrew P; Pickl, Winfried F; Lajoie, Stephane; Wills-Karp, Marsha

Published In Nat Immunol, (2020 07)

Abstract: The molecular basis for the propensity of a small number of environmental proteins to provoke allergic responses is largely unknown. Herein, we report that mite group 13 allergens of the fatty acid-binding protein (FABP) family are sensed by an evolutionarily conserved acute-phase protein, serum amyloid A1 (SAA1), that promotes pulmonary type 2 immunity. Mechanistically, SAA1 interacted directly with allergenic mite FABPs (Der p 13 and Blo t 13). The interaction between mite FABPs and SAA1 activated the SAA1-binding receptor, formyl peptide receptor 2 (FPR2), which drove the epithelial release of the type-2-promoting cytokine interleukin (IL)-33 in a SAA1-dependent manner. Importantly, the SAA1-FPR2-IL-33 axis was upregulated in nasal epithelial cells from patients with chronic rhinosinusitis. These findings identify an unrecognized role for SAA1 as a soluble pattern recognition receptor for conserved FABPs found in common mite allergens that initiate type 2 immunity at mucosal surfaces.

PubMed ID: 32572240

MeSH Terms: No MeSH terms associated with this publication