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Title: Nuclear receptor corepressors in intellectual disability and autism.

Authors: Kong, Yan; Zhou, Wenjun; Sun, Zheng

Published In Mol Psychiatry, (2020 10)

Abstract: Autism spectrum disorder (ASD) is characterized by neurocognitive dysfunctions, such as impaired social interaction and language learning. Gene-environment interactions have a pivotal role in ASD pathogenesis. Nuclear receptor corepressors (NCORs) are transcription co-regulators physically associated with histone deacetylases (HDACs) and many known players in ASD etiology such as transducin β-like 1 X-linked receptor 1 and methyl-CpG binding protein 2. The epigenome-modifying NCOR complex is sensitive to many ASD risk factors, including HDAC inhibitor valproic acid and a variety of endocrine factors, xenobiotic chemicals, or metabolites that can directly bind to multiple nuclear receptors. Here, we review recent studies of NCORs in neurocognition using animal models and human genetics approaches. We discuss functional interplays between NCORs and other known players in ASD etiology. It is conceivable that the NCOR complex may bridge the in utero environmental risk factors of ASD with epigenetic remodeling and can serve as a converging point for many gene-environment interactions in the pathogenesis of ASD and intellectual disability.

PubMed ID: 32034290 Exiting the NIEHS site

MeSH Terms: Animals; Autism Spectrum Disorder*/genetics; Autistic Disorder/genetics; Co-Repressor Proteins*/genetics; Genes, X-Linked; Humans; Intellectual Disability*/genetics

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