Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: Placenta Disrupted: Endocrine Disrupting Chemicals and Pregnancy.

Authors: Gingrich, Jeremy; Ticiani, Elvis; Veiga-Lopez, Almudena

Published In Trends Endocrinol Metab, (2020 07)

Abstract: Endocrine disrupting chemicals (EDCs) are chemicals that can interfere with normal endocrine signals. Human exposure to EDCs is particularly concerning during vulnerable periods of life, such as pregnancy. However, often overlooked is the effect that EDCs may pose to the placenta. The abundance of hormone receptors makes the placenta highly sensitive to EDCs. We have reviewed the most recent advances in our understanding of EDC exposures on the development and function of the placenta such as steroidogenesis, spiral artery remodeling, drug-transporter expression, implantation and cellular invasion, fusion, and proliferation. EDCs reviewed include those ubiquitous in the environment with available human biomonitoring data. This review also identifies critical gaps in knowledge to drive future research in the field.

PubMed ID: 32249015 Exiting the NIEHS site

MeSH Terms: Animals; Endocrine Disruptors/toxicity*; Endocrine System/drug effects; Endocrine System/metabolism; Female; Humans; Placenta/drug effects*; Placenta/metabolism*; Pregnancy; Trophoblasts/drug effects; Trophoblasts/metabolism

Back
to Top