Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: Neoadjuvant Radiotherapy-Related Wound Morbidity in Soft Tissue Sarcoma: Perspectives for Radioprotective Agents.

Authors: Callaghan, Cameron M; Hasibuzzaman, M M; Rodman, Samuel N; Goetz, Jessica E; Mapuskar, Kranti A; Petronek, Michael S; Steinbach, Emily J; Miller, Benjamin J; Pulliam, Casey F; Coleman, Mitchell C; Monga, Varun V; Milhem, Mohammed M; Spitz, Douglas R; Allen, Bryan G

Published In Cancers (Basel), (2020 Aug 12)

Abstract: Historically, patients with localized soft tissue sarcomas (STS) of the extremities would undergo limb amputation. It was subsequently determined that the addition of radiation therapy (RT) delivered prior to (neoadjuvant) or after (adjuvant) a limb-sparing surgical resection yielded equivalent survival outcomes to amputation in appropriate patients. Generally, neoadjuvant radiation offers decreased volume and dose of high-intensity radiation to normal tissue and increased chance of achieving negative surgical margins-but also increases wound healing complications when compared to adjuvant radiotherapy. This review elaborates on the current neoadjuvant/adjuvant RT approaches, wound healing complications in STS, and the potential application of novel radioprotective agents to minimize radiation-induced normal tissue toxicity.

PubMed ID: 32806601 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

Back
to Top