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Publication Detail

Title: An Injectable Microparticle Formulation Provides Long-Term Inhibition of Hypothalamic ERK1/2 Activity and Sympathetic Excitation in Rats with Heart Failure.

Authors: Naguib, Youssef W; Yu, Yang; Wei, Shun-Guang; Morris, Angie; Givens, Brittany E; Mekkawy, Aml I; Weiss, Robert M; Felder, Robert B; Salem, Aliasger K

Published In Mol Pharm, (2020 09 08)

Abstract: Sympathetic excitation contributes to clinical deterioration in systolic heart failure (HF). Significant inhibition of hypothalamic paraventricular nucleus (PVN) ERK1/2 signaling and a subsequent reduction of plasma norepinephrine (NE) levels in HF rats were achieved 2 weeks after a single subcutaneous injection of PD98059-loaded polymeric microparticles, without apparent adverse events, while blank microparticles had no effect. Similar reductions in plasma NE, a general indicator of sympathetic excitation, were previously achieved in HF rats by intracerebroventricular infusion of PD98059 or genetic knockdown of PVN ERK1/2 expression. This study presents a clinically feasible therapeutic approach to the central abnormalities contributing to HF progression.

PubMed ID: 32786958 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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