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National Institute of Environmental Health Sciences

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Publication Detail

Title: Pregnancy-associated changes in cervical noncoding RNA.

Authors: Gerson, Kristin D; Haviland, Miriam J; Neo, Dayna; Hecht, Jonathan L; Baccarelli, Andrea A; Brennan, Kasey Jm; Dereix, Alexandra E; Ralston, Steven J; Hacker, Michele R; Burris, Heather H

Published In Epigenomics, (2020 Jun)

Abstract: Aim: To identify pregnancy-associated changes in cervical noncoding RNA (ncRNA), including miRNA and long noncoding RNA (lncRNA), and their potential effects on biologic processes. Materials & methods: We enrolled 21 pregnant women with term deliveries (≥37 weeks' gestation) in a prospective cohort and collected cervical swabs before 28 weeks' gestation. We enrolled 21 nonpregnant controls. We analyzed miRNA, lncRNA and mRNA expression, applying a Bonferroni correction. Results: Five miRNA and three lncRNA were significantly differentially (>twofold change) expressed. Putative miRNA targets are enriched in genes mediating organogenesis, glucocorticoid signaling, cell adhesion and ncRNA machinery. Conclusion: Differential cervical ncRNA expression occurs in the setting of pregnancy. Gene ontology classification reveals biological pathways through which miRNA may play a biologic role in normal pregnancy physiology.

PubMed ID: 32808540 Exiting the NIEHS site

MeSH Terms: Adult; Case-Control Studies; Cervix Uteri*; Female; Gene Expression Profiling; Humans; MicroRNAs/genetics*; Pregnancy; RNA, Long Noncoding/genetics*

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