Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Characterization of the aryl hydrocarbon receptor repressor and a comparison of its expression in Atlantic tomcod from resistant and sensitive populations.

Authors: Roy, Nirmal K; Courtenay, Simon C; Chambers, R Christopher; Wirgin, Isaac I

Published In Environ Toxicol Chem, (2006 Feb)

Abstract: Atlantic tomcod from the Hudson River, USA, are resistant to cytochrome P4501A1 (CYP1A1) mRNA induction and early life stage toxicities induced by coplanar polychlorinated biphenyls (PCBs) or tetrachlorodibenzo-p-dioxins but not polycyclic aromatic hydrocarbons. We sought to determine if basal expression or inducibility of aryl hydrocarbon receptor repressor (AHRR) mRNA is higher in tomcod from the resistant Hudson River population than in those from sensitive populations. Tomcod AHRR cDNA was characterized and its expression quantified in different tissues and life stages of tomcod from the Hudson River, Miramichi River, Canada (sensitive), and among environmentally exposed tomcod from these two sources and the St. Lawrence River, Canada. Phylogenetic analysis revealed that tomcod AHRR falls within the clade of other vertebrate aryl hydrocarbon receptors (AHRs) but is most closely related to the four previously identified AHRR genes. Induction of AHRR mRNA was observed in all tissues of PCB77-treated juvenile tomcod of Miramichi River descent, and expression differed among tissues and was significantly related to levels of CYPIAI mRNA expression. Aryl hydrocarbon receptor repressor mRNA was similarly inducible in F2 embryos of Miramichi and Hudson River descent by benzo[a]pyrene but less by PCB77 in Hudson River offspring. A significant, positive correlation was observed between CYP1A1 mRNA and AHRR mRNA concentrations in environmentally exposed tomcod from the three rivers. We conclude that differences in basal expression or inducibility of AHRR mRNA are not the mechanistic basis of resistance but that levels of AHRR often mirror those of CYP1A1, suggesting that a common AHR pathway-related mechanism may modulate expression of both genes.

PubMed ID: 16519320 Exiting the NIEHS site

MeSH Terms: Adaptation, Physiological; Amino Acid Sequence; Animals; Base Sequence; Cytochrome P-450 CYP1A1/biosynthesis; Cytochrome P-450 CYP1A1/drug effects; Drug Resistance; Embryo, Nonmammalian/drug effects; Embryo, Nonmammalian/physiology; Gadiformes; Gene Expression Regulation; Molecular Sequence Data; New York; Polychlorinated Biphenyls/adverse effects*; Polycyclic Aromatic Hydrocarbons/adverse effects*; RNA, Messenger; Receptors, Aryl Hydrocarbon/biosynthesis*; Receptors, Aryl Hydrocarbon/drug effects; Repressor Proteins/biosynthesis*; Repressor Proteins/drug effects

to Top