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National Institute of Environmental Health Sciences

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Publication Detail

Title: Role of peroxisome proliferator-activated receptor gamma and its ligands in the treatment of hematological malignancies.

Authors: Garcia-Bates, Tatiana M; Lehmann, Geniece M; Simpson-Haidaris, Patricia J; Bernstein, Steven H; Sime, Patricia J; Phipps, Richard P

Published In PPAR Res, (2008)

Abstract: Peroxisome proliferator-activated receptor gamma (PPARgamma) is a multifunctional transcription factor with important regulatory roles in inflammation, cellular growth, differentiation, and apoptosis. PPARgamma is expressed in a variety of immune cells as well as in numerous leukemias and lymphomas. Here, we review recent studies that provide new insights into the mechanisms by which PPARgamma ligands influence hematological malignant cell growth, differentiation, and survival. Understanding the diverse properties of PPARgamma ligands is crucial for the development of new therapeutic approaches for hematological malignancies.

PubMed ID: 18528522 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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