Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: UVRAG in autophagy, inflammation, and cancer.

Authors: Song, Ying; Quach, Christine; Liang, Chengyu

Published In Autophagy, (2020 02)

Abstract: Macroautophagy/autophagy deregulation has been observed in perpetuated inflammation and the proliferation of tumor cells. However, the mechanisms underlying these changes have yet to be well-identified. UVRAG is one of the key players of autophagy, but its role in vivo remained puzzling. Our recent study utilized a mouse model with inducible expression of a cancer-derived frameshift (FS) mutation in UVRAG that dominant-negatively inhibits wild-type UVRAG, resulting in impaired stimulus-induced autophagy. The systemically compromised autophagy, particularly mitophagy, notably increases inflammation and associated pathologies. Furthermore, our discovery indicates that time-dependent autophagy suppression and ensuing CTNNB1/β-catenin activation may serve as one tumor-promoting mechanism underpinning age-related cancer susceptibility.

PubMed ID: 31905312 Exiting the NIEHS site

MeSH Terms: Animals; Autophagosomes/metabolism; Autophagy*; Frameshift Mutation/genetics; Inflammation/metabolism*; Inflammation/pathology*; Mice; Neoplasms/metabolism*; Neoplasms/pathology*; Signal Transduction; Tumor Suppressor Proteins/genetics; Tumor Suppressor Proteins/metabolism*

to Top