Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: A high-stringency blueprint of the human proteome.

Authors: Adhikari, Subash; Nice, Edouard C; Deutsch, Eric W; Lane, Lydie; Omenn, Gilbert S; Pennington, Stephen R; Paik, Young-Ki; Overall, Christopher M; Corrales, Fernando J; Cristea, Ileana M; Van Eyk, Jennifer E; Uhlén, Mathias; Lindskog, Cecilia; Chan, Daniel W; Bairoch, Amos; Waddington, James C; Justice, Joshua L; LaBaer, Joshua; Rodriguez, Henry; He, Fuchu; Kostrzewa, Markus; Ping, Peipei; Gundry, Rebekah L; Stewart, Peter; Srivastava, Sanjeeva; Srivastava, Sudhir; Nogueira, Fabio C S; Domont, Gilberto B; Vandenbrouck, Yves; Lam, Maggie P Y; Wennersten, Sara; Vizcaino, Juan Antonio; Wilkins, Marc; Schwenk, Jochen M; Lundberg, Emma; Bandeira, Nuno; Marko-Varga, Gyorgy; Weintraub, Susan T; Pineau, Charles; Kusebauch, Ulrike; Moritz, Robert L; Ahn, Seong Beom; Palmblad, Magnus; Snyder, Michael P; Aebersold, Ruedi; Baker, Mark S

Published In Nat Commun, (2020 Oct 16)

Abstract: The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP's tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.

PubMed ID: 33067450 Exiting the NIEHS site

MeSH Terms: Disease/genetics*; Human Genome Project; Humans; Proteome/chemistry; Proteome/genetics*; Proteome/metabolism; Proteomics

Back
to Top