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Title: The twists and turns of left-right asymmetric gut morphogenesis.

Authors: Grzymkowski, Julia; Wyatt, Brent; Nascone-Yoder, Nanette

Published In Development, (2020 10 12)

Abstract: Many organs develop left-right asymmetric shapes and positions that are crucial for normal function. Indeed, anomalous laterality is associated with multiple severe birth defects. Although the events that initially orient the left-right body axis are beginning to be understood, the mechanisms that shape the asymmetries of individual organs remain less clear. Here, we summarize new evidence challenging century-old ideas about the development of stomach and intestine laterality. We compare classical and contemporary models of asymmetric gut morphogenesis and highlight key unanswered questions for future investigation.

PubMed ID: 33046455 Exiting the NIEHS site

MeSH Terms: Animals; Body Patterning/genetics; Body Patterning/physiology; Gastrointestinal Microbiome/genetics; Gastrointestinal Microbiome/physiology*; Gene Expression Regulation, Developmental/genetics; Gene Expression Regulation, Developmental/physiology; Humans; Morphogenesis/genetics; Morphogenesis/physiology; Signal Transduction/genetics; Signal Transduction/physiology*

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