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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Antimicrobial efficacy of platinum-doped silver nanoparticles.

Authors: Wongkamhaeng, Kan; Wang, Junnan; Banas, Jeffrey A; Dawson, Deborah V; Holloway, Julie A; Haes, Amanda J; Denry, Isabelle

Published In J Biomed Mater Res B Appl Biomater, (2020 11)

Abstract: Silver nanoparticles (AgNPs) have been proposed to combat oral infection due to their efficient ionic silver (Ag+ ) release. However, concentrations required for antimicrobial efficacy may not be therapeutically viable. In this work, platinum-doped silver nanoparticles (Pt-AgNPs) were explored to evaluate their potential for enhanced Ag+ release, which could lead to enhanced antimicrobial efficacy against S. aureus, P. aeruginosa, and E. coli. AgNPs doped with 0.5, 1, and 2 mol% platinum (Pt0.5 -AgNPs, Pt1 -AgNPs, and Pt2 -AgNPs) were synthesized by a chemical reduction method. Transmission electron microscopy revealed mixed morphologies of spherical, oval, and ribbon-like nanostructures. Surface-enhanced Raman scattering revealed that the surface of Pt-AgNPs was covered with up to 93% Pt. The amount of Ag+ released increased 16.3-fold for Pt2 -AgNPs, compared to AgNPs. The initial lag phase in bacterial growth curve was prolonged for Pt-AgNPs. This is consistent with a Ag+ release profile that exhibited an initial burst followed by sustained release. Doping AgNPs with platinum significantly increased the antimicrobial efficacy against all species. Pt2 -AgNPs exhibited the lowest minimum inhibitory concentrations, followed by Pt1 -AgNPs, Pt0.5 -AgNPs, and AgNPs, respectively. Doping AgNPs with a small amount of platinum promoted the release of Ag+ , based on the sacrificial anodic effect, and subsequently enhanced their antimicrobial efficacy.

PubMed ID: 32618123 Exiting the NIEHS site

MeSH Terms: Anti-Bacterial Agents/chemistry; Anti-Bacterial Agents/pharmacology*; Escherichia coli/drug effects; Metal Nanoparticles*; Microbial Sensitivity Tests; Nanostructures; Platinum/chemistry; Platinum/pharmacology*; Pseudomonas aeruginosa/drug effects; Silver/chemistry; Silver/pharmacology*; Spectrum Analysis, Raman; Staphylococcus aureus/drug effects

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