Skip Navigation

Publication Detail

Title: Study of Occupational Chromium, Iron, and Nickel Exposure and Amyotrophic Lateral Sclerosis in Denmark.

Authors: Dickerson, Aisha S; Hansen, Johnni; Gredal, Ole; Weisskopf, Marc G

Published In Int J Environ Res Public Health, (2020 11 02)

Abstract: Studies of occupational metal exposures and amyotrophic lateral sclerosis (ALS) have focused primarily on known neurotoxicants, including lead, mercury, selenium, and cadmium. However, these exposures are often co-occurring with other lesser studied metals. We conducted a population-based case-control study with the aim of assessing associations between occupational chromium, iron, and nickel exposures and risk of ALS. We identified ALS cases in Denmark from 1982 through 2013 from the Danish National Patient Registry and matched them to 100 controls based on birth year and sex. Cumulative metal exposures were estimated using job exposure matrices applied to occupational history from the Danish Pension Fund. Although mutually adjusted odds of ALS were higher in men with chromium exposures in the third quartile (aOR = 1.24; 95% CI 0.91, 1.69) and fourth quartile (aOR = 1.19; 95% CI: 0.80, 1.76) compared to those with no exposure, differences did not reach statistical significance. We also observed higher odds of ALS in women with nickel exposures in the third quartile (aOR = 2.21; 95% CI: 1.14, 4.28), but not for the fourth quartile (aOR = 0.61; 95% CI: 0.23, 1.64). Our findings do not suggest associations between occupational exposures to these metals and ALS. However, unavoidable non-differential misclassification from the use of JEMs may have masked truly increased risk.

PubMed ID: 33147887 Exiting the NIEHS site

MeSH Terms: Adult; Aged; Amyotrophic Lateral Sclerosis*/chemically induced; Amyotrophic Lateral Sclerosis*/epidemiology; Case-Control Studies; Chromium*/toxicity; Denmark/epidemiology; Female; Humans; Iron*/toxicity; Male; Middle Aged; Nickel*/toxicity; Occupational Exposure*/adverse effects; Occupational Exposure*/analysis; Risk Factors

Back
to Top