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Title: Time trends in pregnancy-related outcomes among women with type 1 diabetes mellitus, 2004-2017.

Authors: Helman, Sarit; James-Todd, Tamarra M; Wang, Zifan; Bellavia, Andrea; Wyckoff, Jennifer A; Serdy, Shanti; Halprin, Elizabeth; O'Brien, Karen; Takoudes, Tamara; Gupta, Munish; McElrath, Thomas F; Brown, Florence M

Published In J Perinatol, (2020 Aug)

Abstract: OBJECTIVE: To examine time trends in US pregnant women with type 1 diabetes mellitus for maternal characteristics and pregnancy outcomes. STUDY DESIGN: We abstracted clinical data from the medical records of 700 pregnant women from 2004 to 2017. For each time period, means and percentages were calculated. P values for trend were calculated using linear and logistic regression. RESULTS: HbA1c in each trimester was unchanged across the analysis period. The prevalence of nephropathy decreased from 4.8% to 0% (P = 0.002). Excessive gestational weight gain increased (P = 0.01). Gestation length also increased (P = 0.01), as did vaginal deliveries (P = 0.03). There were no change in birthweight over time (P = 0.07) and the percentage of neonates with macrosomia and large for gestational age (LGA) neonates also remained unchanged. CONCLUSION: Obstetric guideline changes may have improved gestation length and mode of delivery; however, other outcomes need more attention, including excessive gestational weight gain, macrosomia, and LGA.

PubMed ID: 32488037 Exiting the NIEHS site

MeSH Terms: Birth Weight; Body Mass Index; Diabetes Mellitus, Type 1*/epidemiology; Diabetes, Gestational*/epidemiology; Female; Fetal Macrosomia/epidemiology; Humans; Infant, Newborn; Overweight; Pregnancy; Pregnancy Outcome/epidemiology; Retrospective Studies

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