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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: The associations between p,p'-DDE levels and plasma levels of lipoproteins and their subclasses in an elderly population determined by analysis of lipoprotein content.

Authors: Jugan, Juliann; Lind, P Monica; Salihovic, Samira; Stubleski, Jordan; Kärrman, Anna; Lind, Lars; La Merrill, Michele A

Published In Lipids Health Dis, (2020 Dec 07)

Abstract: BACKGROUND: Lipoproteins at aberrant levels are known to play a role in cardiovascular disease. The metabolite of the insecticide dichlorodiphenyltrichloroethane (DDT), p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), physically associates with lipids and accumulates in adipose tissue. Little is known about which lipoproteins associate with p,p'-DDE. An association between p,p'-DDE exposure and altered levels of circulating lipids was assessed in a large human cohort using a detailed analysis of lipoprotein content. METHODS: Plasma samples were collected from the subset of 75-year old Swedes in the Prospective Investigation of the Vasculature of Uppsala Seniors (PIVUS) cohort who were not prescribed lipid lowering medication (n = 571). p,p'-DDE concentrations in plasma were measured using high-throughput solid phase extraction and gas chromatography-high resolution mass spectrometry. Analysis of plasma lipoprotein content was performed with nuclear magnetic resonance spectroscopy. RESULTS: Detectable levels of p,p'-DDE were found in the plasma samples of all subjects. Elevated p,p'-DDE levels were associated with increased concentrations of lipoproteins of all diameters, with the exception of high density lipoprotein (HDL) of diameters between 14.3 nm-10.9 nm. Of the lipoprotein constituents, triglycerides were most uniformly associated with elevated p,p'-DDE across lipoproteins. p,p'-DDE was furthermore associated with apolipoprotein B, but not apolipoprotein A1. CONCLUSIONS: The positive associations observed between each lipoprotein class and elevated p,p'-DDE support previous data suggesting that p,p'-DDE interacts with lipoproteins within plasma. It is speculated that both physio-chemical and biological mechanisms may explain why p,p'-DDE does not uniformly associate with lipids across lipoproteins.

PubMed ID: 33287856 Exiting the NIEHS site

MeSH Terms: Aged; Aged, 80 and over; Apolipoprotein A-I/blood; Apolipoprotein B-100/blood; DDT/adverse effects*; Dichlorodiphenyl Dichloroethylene/blood*; Female; Humans; Insecticides/adverse effects*; Lipids/blood; Lipoproteins, HDL/blood; Lipoproteins/blood*; Magnetic Resonance Spectroscopy; Male; Risk Factors; Surveys and Questionnaires; Sweden/epidemiology

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