Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Case-Control Study of Paresthesia Among World Trade Center-Exposed Community Members.

Authors: Marmor, Michael; Thawani, Sujata; Cotrina, Maria Luisa; Shao, Yongzhao; Wong, Ericka S; Stecker, Mark M; Wang, Bin; Allen, Alexander; Wilkenfeld, Marc; Vinik, Etta J; Vinik, Aaron I; Reibman, Joan

Published In J Occup Environ Med, (2020 04)

Abstract: To investigate whether paresthesia of the lower extremities following exposure to the World Trade Center (WTC) disaster was associated with signs of neuropathy, metabolic abnormalities, or neurotoxin exposures.Case-control study comparing WTC-exposed paresthesia cases with "clinic controls" (WTC-exposed subjects without paresthesias), and "community controls" (WTC-unexposed persons).Neurological histories and examination findings were significantly worse in cases than controls. Intraepidermal nerve fiber densities were below normal in 47% of cases and sural to radial sensory nerve amplitude ratios were less than 0.4 in 29.4%. Neurologic abnormalities were uncommon among WTC-unexposed community controls. Metabolic conditions and neurotoxin exposures did not differ among groups.Paresthesias among WTC-exposed individuals were associated with signs of neuropathy, small and large fiber disease. The data support WTC-related exposures as risk factors for neuropathy, and do not support non-WTC etiologies.

PubMed ID: 32049876 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

to Top