Title: Case-Control Study of Paresthesia Among World Trade Center-Exposed Community Members.
Authors: Marmor, Michael; Thawani, Sujata; Cotrina, Maria Luisa; Shao, Yongzhao; Wong, Ericka S; Stecker, Mark M; Wang, Bin; Allen, Alexander; Wilkenfeld, Marc; Vinik, Etta J; Vinik, Aaron I; Reibman, Joan
Published In J Occup Environ Med, (2020 04)
Abstract: To investigate whether paresthesia of the lower extremities following exposure to the World Trade Center (WTC) disaster was associated with signs of neuropathy, metabolic abnormalities, or neurotoxin exposures.Case-control study comparing WTC-exposed paresthesia cases with "clinic controls" (WTC-exposed subjects without paresthesias), and "community controls" (WTC-unexposed persons).Neurological histories and examination findings were significantly worse in cases than controls. Intraepidermal nerve fiber densities were below normal in 47% of cases and sural to radial sensory nerve amplitude ratios were less than 0.4 in 29.4%. Neurologic abnormalities were uncommon among WTC-unexposed community controls. Metabolic conditions and neurotoxin exposures did not differ among groups.Paresthesias among WTC-exposed individuals were associated with signs of neuropathy, small and large fiber disease. The data support WTC-related exposures as risk factors for neuropathy, and do not support non-WTC etiologies.
PubMed ID: 32049876
MeSH Terms: No MeSH terms associated with this publication