Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Semisynthesis of the Organoarsenical Antibiotic Arsinothricin.

Authors: Suzol, Sazzad H; Hasan Howlader, A; Galván, Adriana E; Radhakrishnan, Manohar; Wnuk, Stanislaw F; Rosen, Barry P; Yoshinaga, Masafumi

Published In J Nat Prod, (2020 09 25)

Abstract: Arsinothricin [AST (1)], a new broad-spectrum organoarsenical antibiotic, is a nonproteinogenic analogue of glutamate that effectively inhibits glutamine synthetase. We report the chemical synthesis of an intermediate in the pathway to 1, hydroxyarsinothricin [AST-OH (2)], which can be converted to 1 by enzymatic methylation catalyzed by the ArsM As(III) S-adenosylmethionine methyltransferase. This is the first report of semisynthesis of 1, providing a source of this novel antibiotic that will be required for future clinical trials.

PubMed ID: 32830503 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

Back
to Top