Title: Semisynthesis of the Organoarsenical Antibiotic Arsinothricin.
Authors: Suzol, Sazzad H; Hasan Howlader, A; Galván, Adriana E; Radhakrishnan, Manohar; Wnuk, Stanislaw F; Rosen, Barry P; Yoshinaga, Masafumi
Published In J Nat Prod, (2020 09 25)
Abstract: Arsinothricin [AST (1)], a new broad-spectrum organoarsenical antibiotic, is a nonproteinogenic analogue of glutamate that effectively inhibits glutamine synthetase. We report the chemical synthesis of an intermediate in the pathway to 1, hydroxyarsinothricin [AST-OH (2)], which can be converted to 1 by enzymatic methylation catalyzed by the ArsM As(III) S-adenosylmethionine methyltransferase. This is the first report of semisynthesis of 1, providing a source of this novel antibiotic that will be required for future clinical trials.
PubMed ID: 32830503
MeSH Terms: No MeSH terms associated with this publication