Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: High hsCRP is associated with reduced lung function in structural firefighters.

Authors: Gaughan, Denise M; Christiani, David C; Hughes, Michael D; Baur, Dorothee M; Kobzik, Lester; Wagner, Gregory R; Kales, Stefanos N

Published In Am J Ind Med, (2014 Jan)

Abstract: To assess the association between markers of systemic inflammation and pulmonary function in a population of structural firefighters.We studied male career members of a large Midwestern fire department with questionnaires, spirometry, and high-sensitivity C-reactive protein (hsCRP) as a biomarker of systemic inflammation. We examined percent predicted forced expiratory volume in 1 s (FEV1 %-predicted) and forced vital capacity (FVC%-predicted).Complete data were available for 401 firefighters. Higher hsCRP levels were associated with lower lung function values, after adjusting for confounding variables. Specifically, for every twofold increase in log10-hsCRP, FEV1 %-predicted decreased by a mean 1.5% (95% CI: 0.4, 2.6%) and FVC%-predicted decreased by a mean 1.4% (95% CI: 0.4, 2.3%).hsCRP as a biomarker of systemic inflammation may indicate reduced lung function in structural firefighters.

PubMed ID: 24115029 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

Back
to Top