Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Chronic beryllium disease and glutathione biosynthesis genes.

Authors: Bekris, Lynn M; Viernes, Hannah-Malia A; Farin, Federico M; Maier, Lisa A; Kavanagh, Terrance J; Takaro, Tim K

Published In J Occup Environ Med, (2006 Jun)

Abstract: Because glutathione (GSH) has been reported to be increased in chronic beryllium disease (CBD) and is associated with immune modulation, associations between CBD and gene polymorphisms of the rate-limiting enzyme in GSH synthesis, glutamate cysteine ligase (GCL), were investigated. Glutamate cysteine ligase consists of a catalytic subunit (GCLC) and modifier subunit (GCLM).Patients with CBD, beryllium-sensitized subjects (BeS), and beryllium-exposed subjects without CBD were genotyped for the GCLC GAG trinucleotide repeat polymorphism (GCLC TNR), the GCLC-129 single nucleotide polymorphism (SNP), and the GCLM-588 SNP.Results indicate that GCLC TNR genotype 7/7 is negatively associated with CBD (odds ratio [OR] = 0.28, 95% confidence interval [CI] = 0.08-0.95) and the GCLM-588 C/C SNP genotype is associated with CBD susceptibility (OR = 3.07, 95% CI = 1.00-9.37). No differences were noted in the BeS group.This study suggests that GSH modulation may play a role in CBD pathogenesis, but not in sensitization to beryllium.

PubMed ID: 16766924 Exiting the NIEHS site

MeSH Terms: Aged; Aged, 80 and over; Berylliosis/genetics*; Catalytic Domain; Chronic Disease; Female; Genetic Predisposition to Disease; Genotype; Glutamate-Cysteine Ligase/genetics*; Glutathione/biosynthesis*; Humans; Male; Middle Aged; Polymorphism, Genetic*; Polymorphism, Single Nucleotide

Back
to Top