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Title: Non-Hodgkin's lymphoma, obesity and energy homeostasis polymorphisms.

Authors: Willett, E V; Skibola, C F; Adamson, P; Skibola, D R; Morgan, G J; Smith, M T; Roman, E

Published In Br J Cancer, (2005 Oct 03)

Abstract: A population-based case-control study of lymphomas in England collected height and weight details from 699 non-Hodgkin's lymphoma (NHL) cases and 914 controls. Obesity, defined as a body mass index (BMI) over 30 kg m(-2) at five years before diagnosis,, was associated with an increased risk of NHL (OR = 1.5, 95% CI 1.1-2.1). The excess was most pronounced for diffuse large B-cell lymphoma (OR = 1.9, 95% CI 1.3-2.8). Genetic variants in the leptin (LEP 19G > A, LEP -2548G > A) and leptin receptor genes (LEPR 223Q > R), previously shown to modulate NHL risk, as well as a polymorphism in the energy regulatory gene adiponectin (APM1 276G>T), were investigated. Findings varied with leptin genotype, the risks being decreased with LEP 19AA (OR = 0.7, 95% CI 0.5-1.0) and increased with LEP -2548GA (OR = 1.3, 95% CI 1.0-1.7) and -2548AA (OR = 1.4, 95% CI 1.0-1.9), particularly for follicular lymphoma. These genetic findings, which were independent of BMI, were stronger for men than women.

PubMed ID: 16160698 Exiting the NIEHS site

MeSH Terms: Adolescent; Adult; Base Sequence; Case-Control Studies; DNA Primers; Energy Metabolism; Homeostasis/genetics*; Humans; Leptin/genetics; Lymphoma, Non-Hodgkin/complications; Lymphoma, Non-Hodgkin/genetics*; Lymphoma, Non-Hodgkin/metabolism; Middle Aged; Obesity/complications*; Polymorphism, Genetic*; Receptors, Cell Surface/genetics; Receptors, Leptin

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