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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Pregnancy outcomes, infant mortality, and arsenic in drinking water in West Bengal, India.

Authors: von Ehrenstein, O S; Guha Mazumder, D N; Hira-Smith, M; Ghosh, N; Yuan, Y; Windham, G; Ghosh, A; Haque, R; Lahiri, S; Kalman, D; Das, S; Smith, A H

Published In Am J Epidemiol, (2006 Apr 1)

Abstract: Between 2001 and 2003, the authors studied pregnancy outcomes and infant mortality among 202 married women in West Bengal, India. Reproductive histories were ascertained using structured interviews. Arsenic exposure during each pregnancy, including all water sources used, was assessed; this involved measurements from 409 wells. Odds ratios for spontaneous abortion, stillbirth, neonatal mortality, and infant mortality were estimated with logistic regression based on the method of generalized estimating equations. Exposure to high concentrations of arsenic (> or =200 microg/liter) during pregnancy was associated with a sixfold increased risk of stillbirth after adjustment for potential confounders (odds ratio (OR) = 6.07, 95% confidence interval (CI): 1.54, 24.0; p = 0.01). Arsenic-related skin lesions were found in 12 women who had a substantially increased risk of stillbirth (OR = 13.1, 95% CI: 3.17, 54.0; p = 0.002). The odds ratio for neonatal death was 2.81 (95% CI: 0.73, 10.8). No association was found between arsenic exposure and spontaneous abortion (OR = 1.01, 95% CI: 0.38, 2.70) or overall infant mortality (OR = 1.33, 95% CI: 0.43, 4.04). This study adds to the limited evidence that exposure to high concentrations of arsenic during pregnancy increases the risk of stillbirth. However, there was no indication of the increased rates of spontaneous abortion and overall infant mortality that have been reported in some studies.

PubMed ID: 16524957 Exiting the NIEHS site

MeSH Terms: Arsenic Poisoning/complications*; Arsenic Poisoning/epidemiology*; Confounding Factors (Epidemiology); Female; Humans; India/epidemiology; Infant Mortality*; Infant, Newborn; Interviews; Logistic Models; Pregnancy; Pregnancy Outcome/epidemiology*; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Risk Factors; Water Pollutants, Chemical/analysis*

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