Title: Integrating physical and genetic maps: from genomes to interaction networks.
Authors: Beyer, Andreas; Bandyopadhyay, Sourav; Ideker, Trey
Published In Nat Rev Genet, (2007 Sep)
Abstract: Physical and genetic mapping data have become as important to network biology as they once were to the Human Genome Project. Integrating physical and genetic networks currently faces several challenges: increasing the coverage of each type of network; establishing methods to assemble individual interaction measurements into contiguous pathway models; and annotating these pathways with detailed functional information. A particular challenge involves reconciling the wide variety of interaction types that are currently available. For this purpose, recent studies have sought to classify genetic and physical interactions along several complementary dimensions, such as ordered versus unordered, alleviating versus aggravating, and first versus second degree.
PubMed ID: 17703239
MeSH Terms: Gene Regulatory Networks*; Genetic Techniques*; Genome, Human*; Humans; Models, Biological; Physical Chromosome Mapping*; Signal Transduction/genetics