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Title: Effects of neonatal polychlorinated biphenyl exposure on female sexual behavior.

Authors: Chung, Y W; Nunez, A A; Clemens, L G

Published In Physiol Behav, (2001 Oct)

Abstract: The effects of polychlorinated biphenyls (PCBs) on development and reproduction are well documented. However, very little is known about the effects of PCBs on sexual behavior. In this study, we examined the effects of two commercial PCB mixtures, Aroclor 1221 (A1221) and Aroclor 1254 (A1254), on the development of female sexual behavior and of the incertohypothalamic dopaminergic cells (A11 and A13) in Long-Evans rats. Neonatal exposure to A1254 significantly reduced sexual receptivity and reduced the female's latency to approach a male after an intromission. Neonatal treatment with A1221 did not affect female sexual behavior nor did treatment of adult females with A1221 or A1254. Since sexual behavior is affected by dopamine and since PCBs have been reported to alter dopamine content in the brain, we examined the effects of A1221 or A1254 on dopaminergic cells in the incertohypothalamic region of neonatally exposed rats. None of the treatments significantly affected the number of A11 or A13 neurons that were immunoreactive for tyrosine hydroxylase (TH) or the expression of Fos (i.e., the product of the immediate early gene c-fos) in these dopaminergic neurons. Therefore, the disruption of behavior induced by neonatal treatment with A1254 does not appear to be mediated by toxic effects of the mixture on incertohypothalamic dopaminergic systems.

PubMed ID: 11714501 Exiting the NIEHS site

MeSH Terms: Animals; Animals, Newborn; Aroclors/toxicity*; Chlorodiphenyl (54% Chlorine)/toxicity*; Female; Hypothalamus/drug effects; Neurons/drug effects; Polychlorinated Biphenyls/toxicity*; Rats; Rats, Long-Evans; Receptors, Dopamine/drug effects; Sexual Behavior, Animal/drug effects*; Sexual Maturation/drug effects*

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