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Title: The EcoRV genetic polymorphism of human monoamine oxidase type A is not associated with Parkinson's disease and does not modify the effect of smoking on Parkinson's disease.

Authors: Costa-Mallen, P; Checkoway, H; Fishel, M; Cohen, A W; Smith-Weller, T; Franklin, G M; Swanson, P D; Costa, L G

Published In Neurosci Lett, (2000 Jan 07)

Abstract: We previously observed an association with Parkinson's (PD), and modification of the effect of smoking on PD, by a polymorphism of the monoamine oxidase B (MAO-B) gene. The A form of monoamine oxidase (MAO-A) shares with MAO-B many characteristics that could be relevant to PD, especially proneuroxicant bioactivation and dopamine metabolism. MAO-A is also inhibited by tobacco smoke, which bears an apparent protective effect on PD. We investigated the possibility that MAO-A genetic variants may also be involved in predisposition to PD and in modification of the effect of smoking. Three-hundred and seventy-one subjects--145 idiopathic PD cases and 226 age/gender-matched controls--were genotyped for the EcoRV polymorphism of MAO-A gene which has been related to increased enzyme activity. MAO-A EcoRV polymorphism was neither significantly associated with PD nor did it modify the inverse relationship with smoking. These results suggest that the EcoRV polymorphism of MAO-A is not an important biomarker of PD risk.

PubMed ID: 10643794 Exiting the NIEHS site

MeSH Terms: Adult; Aged; Aged, 80 and over; Biotransformation; Deoxyribonucleases, Type II Site-Specific; Dopamine/metabolism; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Monoamine Oxidase/genetics*; Oxidative Stress; Parkinson Disease/enzymology; Parkinson Disease/genetics*; Polymorphism, Restriction Fragment Length*; Smoking/genetics*

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