Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Gender difference in the interaction of smoking and monoamine oxidase B intron 13 genotype in Parkinson's disease.

Authors: Kelada, Samir N; Costa-Mallen, Paola; Costa, Lucio G; Smith-Weller, Terry; Franklin, Gary M; Swanson, Phillip D; Longstreth Jr, W T; Checkoway, Harvey

Published In Neurotoxicology, (2002 Oct)

Abstract: We tested for gender-specific interactions between smoking and genetic polymorphisms of monoamine oxidase B (MAO-B) intron 13 (G or A allele), monoamine oxidase A (MAO-A) EcoRV (Yor N allele), and dopamine D2 recepor (DRD2) Taq1B (B1 or B2 allele) in a case-control study of 186 incident idiopathic Parkinson's disease (PD) cases and 296 age- and gender-matched controls. The odds ratios (ORs) for PD risk for ever smokers versus never smokers were 0.27 (95% CI: 0.13-0.58) for men of genotype G, and 1.26 (0.60-2.63) for men of genotype A (interaction chi2 = 8.14, P = 0.004). In contrast, for women, the OR for ever smokers versus never smokers were 0.62 (95% CI: 0.25-1.34) and 0.64 (95% CI: 0.18-2.21) for women of genotype GG/GA and AA, respectively (interaction chi2 = 0.001, P = 0.975). No interactions were detected between smoking and either MAO-A EcoRV or DRD2 Taq1B genotypes. These results suggest that a strong gender difference exists with respect to the modifying effect of MAO-B genotype on the smoking association with PD.

PubMed ID: 12428723 Exiting the NIEHS site

MeSH Terms: Adult; Aged; Aged, 80 and over; Data Collection; Deoxyribonucleases, Type II Site-Specific/genetics; Female; Genotype; Humans; Introns/genetics; Introns/physiology; Male; Middle Aged; Monoamine Oxidase/genetics*; Monoamine Oxidase/metabolism; Parkinson Disease/enzymology*; Parkinson Disease/genetics*; Population; Sex Characteristics; Smoking/genetics; Smoking/metabolism*

Back
to Top