Title: Molecular mechanisms of nickel carcinogenesis.
Authors: Costa, Max
Published In Biol Chem, (2002 Jun)
Abstract: A brief review of the molecular mechanisms of nickel carcinogenesis is presented. Molecular mechanisms of nickel carcinogenesis are considered from the point-of-view of nickel-induced gene silencing by DNA hypermethylation in mammalian cells and by its ability to inhibit histone acetylation. Model systems designed to study the molecular mechanism of gene silencing are discussed.
PubMed ID: 12222685
MeSH Terms: Acetylation; Animals; Carcinogens/toxicity*; Chromatin/drug effects; Gene Silencing/drug effects; Histones/drug effects; Histones/metabolism; Humans; Neoplasms/chemically induced*; Neoplasms/pathology; Nickel/toxicity*