Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: A case-control study of cyclin D1 CCND1 870A-->G polymorphism and bladder cancer.

Authors: Cortessis, Victoria K; Siegmund, Kimberly; Xue, Shanyan; Ross, Ronald K; Yu, Mimi C

Published In Carcinogenesis, (2003 Oct)

Abstract: Expression of cyclin D1 is believed to lead to progression through the G1-S cell cycle checkpoint, and both experimental and pathological evidence suggest that over-expression of this protein may increase the risk of several cancers, including transition cell carcinoma of the bladder. Two major transcripts have been described for CCND1, the gene encoding cyclin D1. CCND1 870A-->G, a common single nucleotide polymorphism in the splice donor region of exon 4, may modulate expression of these transcripts, with the A variant resulting in an increased pool of the isozyme encoded by transcript form b. A statistically significant 1.8-fold increased risk for bladder cancer among individuals possessing the A/A genotype was recently reported in a hospital-based case-control study conducted among native Japanese. We conducted a population-based case-control study of incidence of bladder cancer among non-Hispanic whites in Los Angeles County to examine the relationship between CCND1 870A-->G genotypes and bladder cancer risk. No association between the A/A genotype and risk was observed (odds ratio = 0.90, 95% confidence interval 0.60-1.33). The null association was not appreciably modified by bladder cancer risk factors, including lifetime smoking history, or by histopathologic classification.

PubMed ID: 12896908 Exiting the NIEHS site

MeSH Terms: Adult; Bladder Neoplasms/genetics*; Case-Control Studies; Cyclin D1/genetics*; Female; Genetic Predisposition to Disease*; Humans; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Single Nucleotide*; Research Support, U.S. Gov't, P.H.S.; Risk Factors

Back
to Top