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National Institute of Environmental Health Sciences

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Publication Detail

Title: The effect of CYP19 and COMT polymorphisms on exercise-induced fat loss in postmenopausal women.

Authors: Tworoger, Shelley S; Chubak, Jessica; Aiello, Erin J; Yasui, Yutaka; Ulrich, Cornelia M; Farin, Federico M; Stapleton, Patricia L; Irwin, Melinda L; Potter, John D; Schwartz, Robert S; McTiernan, Anne

Published In Obes Res, (2004 Jun)

Abstract: OBJECTIVE: To examine whether genetic polymorphisms in CYP19 [intron 4 (TTTA)n; n = 7 to 13 and a 3-base pair deletion, which is in strong linkage disequilibrium with the seven repeat] and COMT (Val108/158Met) modified the change in BMI, total and percentage body fat, or subcutaneous and intra-abdominal fat during a year-long exercise intervention trial. These genes metabolize estrogens and androgens, which are important in body fat regulation. RESEARCH METHODS AND PROCEDURES: A randomized intervention trial was used, with an intervention goal of 225 min/wk of moderate-intensity exercise for one year. Participants (n = 173) were postmenopausal, 50 to 75 years old, sedentary, overweight or obese, and not taking hormone therapy at baseline. RESULTS: Exercisers with two vs. no CYP19 11-repeat alleles had a larger decrease in total fat (-3.1 kg vs. -0.5 kg, respectively, p = 0.01) and percentage body fat (-2.4% vs. -0.6%, respectively, p = 0.001). Exercisers with the COMT Met/Met vs. Val/Val genotype had a smaller decrease in percentage fat (-0.7% vs. -1.9%, respectively, p = 0.05). Among exercisers, women with the COMT Val/Val genotype and at least one copy of the CYP19 11-repeat allele vs. those with neither genotype/allele had a significantly larger decrease in BMI (-1.0 vs. +0.1 kg/m2, respectively, p = 0.009), total fat (-2.9 vs. -0.5 kg, respectively, p = 0.004), and percentage body fat (-2.6% vs. -0.4%, respectively, p < 0.001). DISCUSSION: Genetic polymorphisms in CYP19 and COMT may be important for body fat regulation and possibly modify the effect of exercise on fat loss in postmenopausal women.

PubMed ID: 15229337 Exiting the NIEHS site

MeSH Terms: Adipose Tissue/enzymology*; Adipose Tissue/metabolism; Aged; Alleles; Aromatase/genetics*; Aromatase/metabolism; Body Composition; Catechol O-Methyltransferase/genetics*; Catechol O-Methyltransferase/metabolism; DNA/chemistry; DNA/genetics; Exercise/physiology*; Female; Genotype; Humans; Linear Models; Middle Aged; Obesity/enzymology*; Obesity/genetics; Obesity/metabolism; Polymerase Chain Reaction; Polymorphism, Single Nucleotide/physiology; Postmenopause/metabolism*; Research Support, U.S. Gov't, P.H.S.; Weight Loss/genetics*

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