Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Bias in estimating association parameters for longitudinal binary responses with drop-outs.

Authors: Fitzmaurice, G M; Lipsitz, S R; Molenberghs, G; Ibrahim, J G

Published In Biometrics, (2001 Mar)

Abstract: This paper considers the impact of bias in the estimation of the association parameters for longitudinal binary responses when there are drop-outs. A number of different estimating equation approaches are considered for the case where drop-out cannot be assumed to be a completely random process. In particular, standard generalized estimating equations (GEE), GEE based on conditional residuals, GEE based on multivariate normal estimating equations for the covariance matrix, and second-order estimating equations (GEE2) are examined. These different GEE estimators are compared in terms of finite sample and asymptotic bias under a variety of drop-out processes. Finally, the relationship between bias in the estimation of the association parameters and bias in the estimation of the mean parameters is explored.

PubMed ID: 11252590 Exiting the NIEHS site

MeSH Terms: Algorithms; Bias*; Biometry; Humans; Longitudinal Studies*; Models, Statistical

Back
to Top