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Title: Mechanisms of the blood-brain barrier disruption in HIV-1 infection.

Authors: Toborek, Michal; Lee, Yong Woo; Flora, Govinder; Pu, Hong; András, Ibolya E; Wylegala, Edward; Hennig, Bernhard; Nath, Avindra

Published In Cell Mol Neurobiol, (2005 Feb)

Abstract: (1) Alterations of brain microvasculature and the disruption of the blood-brain barrier (BBB) integrity are commonly associated with human immunodeficiency virus type 1 (HIV-1) infection. These changes are most frequently found in human immunodeficiency virus-related encephalitis (HIVE) and in human immunodeficiency virus-associated dementia (HAD). (2) It has been hypothesized that the disruption of the BBB occurs early in the course of HIV-1 infection and can be responsible for HIV-1 entry into the CNS. (3) The current review discusses the mechanisms of injury to brain endothelial cells and alterations of the BBB integrity in HIV-infection with focus on the vascular effects of HIV Tat protein. In addition, this review describes the mechanisms of the BBB disruption due to HIV-1 or Tat protein interaction with selected risk factors for HIV infection, such as substance abuse and aging.

PubMed ID: 15962513 Exiting the NIEHS site

MeSH Terms: AIDS Dementia Complex/immunology; AIDS Dementia Complex/physiopathology*; Blood-Brain Barrier/immunology; Blood-Brain Barrier/physiopathology*; Blood-Brain Barrier/virology*; HIV-1*; Humans

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