Title: Functional genomic of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism.
Authors: Costa, Lucio G; Cole, Toby B; Jarvik, Gail P; Furlong, Clement E
Published In Annu Rev Med, (2003)
Abstract: This review focuses on the functional genomics of the human paraoxonase (PON1) polymorphisms. Levels and genetic variability of the PON1 position 192 isoforms (Gln/Arg) influence sensitivity to specific insecticides or nerve agents and risk for cardiovascular disease. A more recent area of investigation, the role of PON1 in drug metabolism, is also discussed. We emphasize the importance of considering both PON1 isoforms and PON1 levels in disease/sensitivity association studies.
PubMed ID: 12525679
MeSH Terms: Animals; Aryldialkylphosphatase; Carotid Stenosis/genetics; Chromosome Mapping; Chromosomes, Human, Pair 7; Coronary Arteriosclerosis/genetics; Esterases/genetics*; Ethnic Groups/genetics; Genetic Predisposition to Disease/genetics; Humans; Insecticides/metabolism*; Insecticides/toxicity; Linkage Disequilibrium; Metabolic Detoxication, Drug/genetics; Organophosphorus Compounds*; Polymorphism, Genetic/genetics*; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Risk Factors