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Title: Application of urinary mutagen testing to detect workplace hazardous exposure and bladder cancer.

Authors: Choi, B C; Connolly, J G; Zhou, R H

Published In Mutat Res, (1995 Jan)

Abstract: The objectives of this biochemical epidemiologic case-control study were to evaluate urinary mutagen testing for occupational exposure assessment, and for possible screening for bladder cancer in the workplace. Thirty-seven patients (19 bladder cancer cases and 18 controls) completed a questionnaire. Two urine samples, i.e. a work sample taken while at work, and a home sample, were requested from each patient. Twenty-six patients (17 cases and 9 controls) gave a total of 47 24-h urine samples for mutagenicity testing by the Ames test. A positive Ames test was found to be associated significantly with current occupation with hazardous exposure (odds ratio = 3.7, 95%CI 1.1-12.9), and non-significantly with bladder cancer (odds ratio = 1.8, 95%CI 0.5-7.1). Our results show that the urinary Ames test has the potential of being used as a surveillance for current workplace hazardous exposure (sensitivity = 52%, specificity = 77%, positive predictive value = 72%, negative predictive value = 59%, positive likelihood ratio = 2.3), but not as a screening test for bladder cancer cases (sensitivity = 42%, specificity = 71%, positive predictive value = 3%, negative predictive value = 98%, positive likelihood ratio = 1.5).

PubMed ID: 7529362 Exiting the NIEHS site

MeSH Terms: Adult; Aged; Case-Control Studies; Environmental Monitoring; Evaluation Studies as Topic; Female; Humans; Male; Middle Aged; Mutagenicity Tests*; Mutagens/analysis*; Occupational Exposure*; Occupations; Salmonella typhi/drug effects; Smoking; Urinary Bladder Neoplasms/urine*; Urine*

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