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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease.

Authors: Checkoway, H; Franklin, G M; Costa-Mallen, P; Smith-Weller, T; Dilley, J; Swanson, P D; Costa, L G

Published In Neurology, (1998 May)

Abstract: In a population-based case-control study, we found a reversal of the association of cigarette smoking with Parkinson's disease (PD) in relation to the monoamine oxidase B intron 13 genetic polymorphism. A reduced PD risk related to pack-years of smoking was detected for persons with the G allele, whereas an opposite effect was found among persons with the A allele. These results indicate an unexplained interaction between cigarette smoking and this genetic polymorphism.

PubMed ID: 9596006 Exiting the NIEHS site

MeSH Terms: Adult; Aged; Aged, 80 and over; Case-Control Studies; Female; Genotype; Humans; Male; Middle Aged; Monoamine Oxidase/genetics*; Parkinson Disease/etiology*; Parkinson Disease/genetics; Polymorphism, Genetic*; Risk Factors; Smoking/adverse effects*

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