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Publication Detail

Title: B[a]P-DNA binding in early life-stages of Atlantic tomcod: population differences and chromium modulation.

Authors: Sorrentino, C; Roy, N K; Chambers, R C; Courtenay, S C; Wirgin, I

Published In Mar Environ Res, (2004 Aug-Dec)

Abstract: Atlantic tomcod (Microgadus tomcod) from the Hudson River (HR) are resistant at the molecular and organismic levels to the effects of exposure to dioxin-like aromatic hydrocarbon (AH) compounds, but much less so to benzo[a]pyrene (B[a]P). The aims of this study were to determine in early life-stages of tomcod exposed to B[a]P: (1) if DNA binding levels differed between fish from the HR and Miramichi River (MR), and (2) if co-exposure to chromium could modulate this genotoxic effect. After exposure to [(3)H]B[a]P alone, DNA-bound radioactivity was 5-10-fold higher in embryos and larvae of MR than HR descent. Co-exposure to chromium modulated DNA binding levels in offspring of both populations. In MR embryos, co-exposure to chromium inhibited B[a]P uptake. These results demonstrated resistance to the genotoxic effects of B[a]P in early life stages of HR tomcod at an ecologically important endpoint and suggest the ability of chromium to modulate AH-induced genotoxicity.

PubMed ID: 15178057 Exiting the NIEHS site

MeSH Terms: Animals; Benzo(a)pyrene/metabolism*; Chromium/metabolism*; DNA/metabolism*; Embryo, Nonmammalian/metabolism; Fishes/metabolism*; Larva/metabolism; New Brunswick; New York; Rivers; Species Specificity; Tritium

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